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American Society of Microbiology ABMM Sample Questions (Q111-Q116):
NEW QUESTION # 111
A research laboratory is investigating the mechanisms of antiviral drug resistance. They are studying a herpes simplex virus strain that has developed resistance to acyclovir. The MOST common mechanism of acyclovir resistance in HSV involves mutations in the gene encoding:
Answer: D
NEW QUESTION # 112
A clinical microbiology laboratory is investigating a potential outbreak of Legionella pneumophila associated with a hospital's water system. The MOST appropriate environmental samples to collect for culture and comparison to clinical isolates would be:
Answer: C
NEW QUESTION # 113
Metagenomic analysis of a bronchoalveolar lavage (BAL) sample from a patient with severe pneumonia reveals a complex microbial community with a high abundance of both bacterial and fungal sequences. This approach is particularly useful in identifying:
Answer: A
NEW QUESTION # 114
A research laboratory is investigating the mechanism of action of a novel antiviral compound that inhibits the replication of a specific RNA virus. They find that the compound binds directly to the viral RNA-dependent RNA polymerase, preventing its elongation activity. This mechanism is most similar to that of:
Answer: C
NEW QUESTION # 115
A clinical microbiology laboratory is monitoring the emergence of resistance to colistin in Gram-negative bacteria. Resistance to colistin is often mediated by modifications of the bacterial lipopolysaccharide (LPS).
The genetic basis for acquired colistin resistance most commonly involves:
Answer: B
NEW QUESTION # 116
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